Archive

Volume 9, Issue 1, June 2025

  • Research Article

    Relationship Between Serum Vitamin D and Adrenal-derived Androgens Upon Castrate-Resistant Prostate Cancer Diagnosis

    Collins Amadi*, Johnbosco Chidozie Okafor, Ezra Agbo

    Issue: Volume 9, Issue 1, June 2025
    Pages: 1-11
    Received: 10 January 2025
    Accepted: 27 January 2025
    Published: 17 February 2025
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    Abstract: Introduction: Following primary androgen deprivation therapy (PADT) for prostate cancer (PCa) treatment, most patients develop castration-resistant PCa (CRPC). Intra-prostatic biosynthesis of androgens from adrenal-derived precursor androgens promotes CRPC evolution after PADT and vitamin D (VitD) have been shown to inhibit this intra-prostatic bio... Show More
  • Research Article

    Omega-3 Fatty Acids as a Novel Antioxidant Strategy Against Cadmium-induced Testicular Dysfunction: A Proteomic Approach

    Fidelis Ohiremen Oyakhire*, Mathias Abiodun Emokpae, Kelly Iria Esezobor, Babatunde Ishola Gabriel Adejumo, Samson Efenarhua, Juliana Edusola Olaniyan, Emmanuel Onosetale Afeikhena, Adolphus Osakpolor Ogbebor, Aigbokhan Akhere Caleb, Eboselume Osamudiamen Joshua, Vani Onotinamhe Usman-Onoruvie, Patricia Ejenawome Dele-Ochie, Grace Eleojo Obasuyi, Basheer Madompoyil, Sadeeq Abdulsalam

    Issue: Volume 9, Issue 1, June 2025
    Pages: 12-31
    Received: 27 June 2025
    Accepted: 14 July 2025
    Published: 7 August 2025
    DOI: 10.11648/j.plm.20250901.12
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    Abstract: Background: Cadmium-induced reproductive toxicity significantly threatens male fertility, primarily through oxidative stress and alterations in testicular proteins. Objective: This study investigates omega-3 fatty acids as a potential therapeutic strategy to counteract cadmium-induced testicular damage. Methods Adult male Wistar rats were exposed t... Show More
  • Research Article

    International Translational Medicine in World Healthcare

    Evgeniy Bryndin*

    Issue: Volume 9, Issue 1, June 2025
    Pages: 32-37
    Received: 27 August 2025
    Accepted: 9 September 2025
    Published: 9 October 2025
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    Abstract: Translational medicine areas include areas aimed at applying the results of basic research to develop new methods for diagnosing, treating and preventing diseases. The main areas of translational medicine are, firstly, personalized medicine — development of individual approaches to treatment based on the patient’s genetic, molecular and clinical in... Show More