Propylthiouracil: An Intriguing Connection Among the Propylthiouracil, Hypothyroidism, and Obesity
Uzma Naz Shaikh,
Muhammad Ali Ghoto,
Abdullah Dayo,
Mudassar Iqbal Arain,
Rabia Parveen
Issue:
Volume 6, Issue 1, June 2022
Pages:
1-6
Received:
12 January 2022
Accepted:
14 February 2022
Published:
28 February 2022
Abstract: Hypothyroidism and obesity both are medical conditions that have been connected closely. 6- Propyl-2-thiouracil (PTU) is an anti-thyroid drug usually used to treat overactive thyroid, but may cause obesity, which rises morbidity and mortality of patients. Object To explore the prevalence of obesity in hypothyroid patients, who were receiving PTU for the management of overactive thyroid. The aims of current research to access the drug utilization and investigation of PTU which aids in attaining rational therapy and other aspects related to patient’s safety. Method: A cross-sectional research was conducted and 200 participants with overactive thyroid selected by non-probably consecutive sampling method from POD #4 at Liaquat University of Medical and Health Sciences, Hospital, Jamshoro from May 2016 to April 2017 and all adults with overactive thyroid receiving Propylthiouracil were included. Their Thyroid function tests performed on Immunoassay Elecysis 2010 and entire data was evaluated via SPSS version 22.0. Result: The data revealed that the PTU-induced obesity in 52 hypothyroid patients (n=14 males, n=38 females) and the prevalence of PTU-induced obesity was 26.0%. Conclusion: It was perceived that PTU alters the function of thyroid stimulating hormone (TSH) or thyrotropin and increases the amount of thyrotropin would will be secondary to obesity.
Abstract: Hypothyroidism and obesity both are medical conditions that have been connected closely. 6- Propyl-2-thiouracil (PTU) is an anti-thyroid drug usually used to treat overactive thyroid, but may cause obesity, which rises morbidity and mortality of patients. Object To explore the prevalence of obesity in hypothyroid patients, who were receiving PTU fo...
Show More
Pityriasis Rosea Gibert - Disease History and New Findings
Issue:
Volume 6, Issue 1, June 2022
Pages:
7-10
Received:
30 May 2022
Accepted:
20 June 2022
Published:
30 June 2022
Abstract: The author's aim in this article is to describe a common exanthematic disease typical of adolescence, pityriasis rosea Gibert, in the light of new findings. Another aim is to draw attention to an overlooked fact about the difficulty and inconsistency of therapy with the recommended course of action. The author uses his own experience from his many years of dermatological practice and adds facts from current literature sources on the disease. The meaning of the disease name is explained and the historical implications of the disease name are clarified. The current view of its probable viral etiopathogenesis and its similarity to another exanthematous skin disease, exanthema subitum, are described. The prodromal stage of the disease and the clinical picture of the skin findings with characteristic seeding of lesions resembling "Christmas tree branches" are described. The author's clinical pictures of the findings in individual patients with this disease are included. The possible relationship with COVID-19 is noted. The differential diagnosis is discussed, including the similarity to secondary syphilis, and the uncharacteristic histopathological picture of the disease is described. Finally, treatment options are discussed, with the caveat that the very common use of topical corticosteroids is not very effective and rather non-corticoid external therapy is recommended. The author draws attention to the possible alteration of the psychological state of predominantly adolescent patients due to the frequent long persistence of cutaneous, and therefore visible, symptoms.
Abstract: The author's aim in this article is to describe a common exanthematic disease typical of adolescence, pityriasis rosea Gibert, in the light of new findings. Another aim is to draw attention to an overlooked fact about the difficulty and inconsistency of therapy with the recommended course of action. The author uses his own experience from his many ...
Show More
