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Hydatid Cyst of the Kidney: About Two Rare Cases
Oukkas Siham,
El Mezouari El mostafa,
Redouane Rhoukhsi,
Redouane Moutaj
Issue:
Volume 1, Issue 1, December 2017
Pages:
1-4
Received:
26 January 2017
Accepted:
13 February 2017
Published:
2 March 2017
DOI:
10.11648/j.plm.20170101.11
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Abstract: Hydatidosis is a rare parasitic disease that is endemic in some countries of the Mediterranean basin. Renal localization is rare and exists only in 5% of the visceral forms. The diagnosis of hydatid cyst of the kidney is suspected in epidemiological, clinical, radiological and biological arguments. The clinical symptomatology is variable, and depends on the evolutionary stage of the cyst. Hydration is the only pathognomonic sign, but it exists in only 10 to 30% of cases. Ultrasound makes it possible to suspect the hydatic nature of the lesion in more than 50% of cases; Computed tomography and magnetic resonance imaging are useful in cases of diagnostic doubt. The reference treatment of the renal hydatid cyst is Conservative surgery with resection of the protruding dome. A total nephrectomy is conceived only in front of a kidney completely destroyed.
Abstract: Hydatidosis is a rare parasitic disease that is endemic in some countries of the Mediterranean basin. Renal localization is rare and exists only in 5% of the visceral forms. The diagnosis of hydatid cyst of the kidney is suspected in epidemiological, clinical, radiological and biological arguments. The clinical symptomatology is variable, and depen...
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Hepatoprotective Activity of Aqueous and Ethanol Extract of Lippia adoensis Leaf Against Carbon Tetrachloride-Induced Hepatotoxicity in Mice
Yared Wasihun,
Eyasu Makonnen,
Mekbeb Afewerk,
Wondwossen Ergete
Issue:
Volume 1, Issue 1, December 2017
Pages:
5-13
Received:
27 June 2016
Accepted:
9 March 2017
Published:
10 March 2017
DOI:
10.11648/j.plm.20170101.12
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Abstract: Liver disease is one of the fatal diseases. Medicinal plants may serve as one ofthe best sources of remedies for treatment of liver disease. Identification of a potential therapeutic agent for protection of liver from hepatotoxins provides a useful way for the prevention of liver related illnesses. The aim of the present study was, therefore, to investigate the hepatoprotective activity of 80% ethanolic and aqueous extract of leaves of Lippia adoensis againstcarbontetrachloride induced liver injury in mice. Mice were pretreated with extract of Lippia adoensis (200 & 400 mg/kg bw. po) for 7 days and then challenged with CCl4 (0.2 ml/100 gm p. o) on the 7th day. Serum biomarkers (AST, ALT, ALP and total bilirubin, total protein and albumin) were estimated in all the study groups. Histopathological examination was also carried out for all groups of mice. CCl4 significantly (P < 0.001) increased the AST, ALT, ALP and total bilirubin levels and decreased the level of total protein and albumin indicating hepatic damage. Pretreatment with theextract of Lippia adoensis (200 & 400 mg/kg) produced significant (P < 0.001) hepatoprotective effects as evidenced by decreased serum enzymes (AST, ALT, ALP) and serum bilirubin and increase the level of total protein and albumin as well as by histopathological findings of the liver. Histopathological examination of the liver tissues of CCl4 group represented the presence of marked foci of mononuclear infiltration in the hepatic parenchyma tissue, sinusoid and around central vein, as well as disorganization of hepatic plates, whilepretreatment with extract of Lippia adoensis overcome most of these changes to normal histological architecture of the liver. Body weights of Lippia adoensis extract treated groups increased significantly (P < 0.001) as compared to carbontetrachloride treated group. The absolute and relative liver weights of extracts treated mice decreased significantly (P < 0.001) as compared to those treated with CCl4. The results obtained from both ethanolic and aqueous extract of Lippia adoensis were comparable with those of the standard drug, Silymarin. It can be concluded from the present study that bothethanolic and aqueous extracts of Lippia adoensis have hepatoprotective effect.
Abstract: Liver disease is one of the fatal diseases. Medicinal plants may serve as one ofthe best sources of remedies for treatment of liver disease. Identification of a potential therapeutic agent for protection of liver from hepatotoxins provides a useful way for the prevention of liver related illnesses. The aim of the present study was, therefore, to in...
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Molecular Study of FLT3-ITD Mutation in Iraqi Adult Acute Myeloid Leukemia Patients; Its Correlation with Clinicopathological Parameters
Shaymaa Abdulateef,
Ali Almothaffar,
Khitam Razzak Al-khafaji
Issue:
Volume 1, Issue 1, December 2017
Pages:
14-17
Received:
3 March 2017
Accepted:
21 March 2017
Published:
19 April 2017
DOI:
10.11648/j.plm.20170101.13
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Abstract: Acute myeloid leukemia (AML) is a hematological malignancy of myeloid progenitor cells characterized by abnormal proliferation, inhibition of differentiation and expansion of leukemic cells prevented at the early step of hematopoiesis. Detection of molecular markers has become a smart tool to further division of patients in AML subgroups. The Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations are found in about 20-25% of AML patients and it is associated with increased transcript level of FLT3 and with unfortunate prognosis in adult AML patients. This study aims to find FLT3-ITD mutation in Iraqi adult newly diagnosed AML patients using real time-PCR technique and gel electrophoresis post PCR procedure as well as to evaluate the relationship of FLT3-ITD mutation with clinicopathological parameters including age, gender, total WBC count and FAB subtypes of the disease. FLT3-ITD mutation was found in 1.88% of AML patients. FLT3-ITD mutation was not related to any clinical variables including age, gender, total WBC count and FAB subtypes of the disease with statistical significance. These findings suggest low rate of FLT3-ITD is found in Iraqi adult AML patients and no correlations are established between FLT3-ITD mutation and any clinical variables of AML including age, gender, total WBC count and FAB subtypes of the disease.
Abstract: Acute myeloid leukemia (AML) is a hematological malignancy of myeloid progenitor cells characterized by abnormal proliferation, inhibition of differentiation and expansion of leukemic cells prevented at the early step of hematopoiesis. Detection of molecular markers has become a smart tool to further division of patients in AML subgroups. The Fms-l...
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Simultaneous Determination of Each Component in the Salbcain Injection
Chung-Mi Jang,
Yang-Chun Ri,
Un-Chol Rim,
Myong-Il Ri
Issue:
Volume 1, Issue 1, December 2017
Pages:
18-21
Received:
24 February 2017
Accepted:
13 June 2017
Published:
26 July 2017
DOI:
10.11648/j.plm.20170101.14
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Abstract: It has determinated Sodium salicylate, Lidocaine hydrochloride and Thiamine hydro-chloride in the Salbcain injection by using an ultraviolet spectrophotometry and Kalman filter simultaneously, it has found that wavelength range for simultaneous determination were from 268.6 nm to 332.0 nm. And in this wavelength condition, this determination method for the Salbcain injection was accurate and precise (mean recovery: respectively 99.91%, 97.10% and 99.11%, coefficient of variation: respectively 0.06%, 0.99% and 0.24% of Sodium salicylate, Lidocaine hydrochloride and Thiamine hydrochloride). So it has could determinate the each component of the Salbcain injection simultaneously without chemical reagents.
Abstract: It has determinated Sodium salicylate, Lidocaine hydrochloride and Thiamine hydro-chloride in the Salbcain injection by using an ultraviolet spectrophotometry and Kalman filter simultaneously, it has found that wavelength range for simultaneous determination were from 268.6 nm to 332.0 nm. And in this wavelength condition, this determination method...
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