Report
Plant Pathology - Crossing the Boundaries with Novel Approaches and Perspectives for Scientists
Tsigehana Yewste Mamo*
Issue:
Volume 8, Issue 1, December 2024
Pages:
1-8
Received:
19 April 2024
Accepted:
23 May 2024
Published:
20 August 2024
Abstract: The review "Plant Pathology: Crossing the Boundaries: Novel Approaches and Perspectives for Scientists" explores the evolving field of plant pathology, emphasizing the necessity for innovative strategies and interdisciplinary collaboration to address the challenges posed by plant diseases. It highlights the integration of cutting-edge technologies, such as genomics and omics techniques, with ecological perspectives to better understand disease dynamics and develop sustainable management solutions. Traditional methods are insufficient to tackle the complex nature of plant diseases that threaten agriculture and ecosystems. The review points to the transformative potential of advanced technologies. Genomics offers deep insights into the genetic structures of pathogens and their interactions with host plants, crucial for identifying disease-resistant varieties and developing targeted treatments. Omics techniques, including transcriptomics, proteomics, and metabolomics, provide comprehensive views of molecular changes during plant-pathogen interactions, aiding in the identification of biomarkers for early disease detection and understanding mechanisms of plant resistance and susceptibility. Moreover, the review underscores the importance of an ecological approach to plant pathology. Understanding disease dynamics in the context of ecological systems reveals how environmental factors like climate change and biodiversity influence the emergence and spread of diseases. This ecological perspective is essential for developing robust and adaptable disease management strategies. The review advocates for crossing disciplinary boundaries and promoting collaboration among scientists from diverse fields. Such interdisciplinary efforts are crucial for advancing understanding and creating effective control strategies. Collaboration among molecular biologists, ecologists, agronomists, and other specialists can lead to innovative solutions addressing the root causes of plant diseases and reducing their impact on agriculture and natural ecosystems. In summary, the review emphasizes the need for novel approaches that combine cutting-edge technologies with ecological insights. Interdisciplinary collaboration is essential to enhance the understanding of plant diseases and to develop sustainable management practices. This comprehensive approach is vital for ensuring food security and maintaining ecosystem resilience in the face of emerging plant disease threats. The integration of these innovative strategies aims to meet the global demand for sustainable agricultural productivity and the health of natural ecosystems.
Abstract: The review "Plant Pathology: Crossing the Boundaries: Novel Approaches and Perspectives for Scientists" explores the evolving field of plant pathology, emphasizing the necessity for innovative strategies and interdisciplinary collaboration to address the challenges posed by plant diseases. It highlights the integration of cutting-edge technologies,...
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Case Report
Papillary Intralymphatic Angioendothelioma of the Spleen: A Rare Lymphatic Tumour in the Context of a PIK3CA Mutation
Issue:
Volume 8, Issue 1, December 2024
Pages:
9-14
Received:
29 August 2024
Accepted:
18 September 2024
Published:
10 October 2024
Abstract: Papillary intralymphatic angioendothelioma (PILA) is a locally aggressive, rarely metastasising lymphatic tumour that typically arises within the skin and soft tissues. We report a case of PILA arising within the spleen of a 6-year-old boy with megacephaly-capillary malformation (MCAP/MC-M) syndrome. MCAP/MC-M represents part of the phosphatidylinositol-4,5-biphosphate 3 kinase catalytic subunit alpha (PIK3CA) related overgrowth spectrum (PROS). This is the 6th reported case in the literature of a splenic PILA and the 2nd known to have occurred in the context of a confirmed PIK3CA mutation. In reporting this case we review prior reports of PILA occurring within the spleen and discuss the potential role of the PIK3CA mutation in the aetiology of the lesion, and note a theoretical application of mammalian target of rapamycin (mTOR) inhibitors as a possible therapeutic strategy.
Abstract: Papillary intralymphatic angioendothelioma (PILA) is a locally aggressive, rarely metastasising lymphatic tumour that typically arises within the skin and soft tissues. We report a case of PILA arising within the spleen of a 6-year-old boy with megacephaly-capillary malformation (MCAP/MC-M) syndrome. MCAP/MC-M represents part of the phosphatidylino...
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Research Article
RANK-RANKL-OPG System in COVID-19: Examining the Pathway Among Healthcare Workers in Nigeria
Issue:
Volume 8, Issue 1, December 2024
Pages:
15-22
Received:
14 August 2024
Accepted:
10 September 2024
Published:
29 October 2024
Abstract: Background: Coronavirus disease 2019 (COVID-19) influences bone metabolism by altering the RANK-RANKL-OPG system. However, this has not been validated, especially among Nigerians. Consequently, the current study explored the influence of the disease on this vital skeletal pathway among Nigerian healthcare workers (HCWs). Methods: This was a prospective longitudinal study conducted in the Department of Chemical Pathology of the Rivers State University Teaching Hospital among HCWs in Rivers State, Southern Nigeria. Eligible HCWs (n=76) with moderate RT-PCR-confirmed COVID-19 were recruited and compared with age and sex-matched healthy controls. Demographic, anthropometric, clinical, and laboratory data were obtained at baseline upon COVID-19 onset and followed up on days four and seven. Statistical analysis was done using descriptive/inferential statistics at a p-value <0.05. Results: The HCWs with moderate COVID-19 had higher serum levels of pro-inflammatory markers (IL-1β, IL-6, TNF-α) and receptor activator of nuclear factor kappa beta ligand (RANKL) but lower serum levels of osteoprotegerin (OPG) t COVID-19 diagnosis compared to the healthy controls (p<0.05). Among the HCWs with positive COVID-19 status, an increasing trend of these inflammatory markers and RANKL was observed from day one to day four and day seven, but a decreasing trend of OPG levels was observed (p<0.05). On day seven following COVID-19 diagnosis among the HCWs, a positive relationship was established between serum RANKL and all the pro-inflammatory markers (p<0.001) while an inverse relationship was only observed between OPG and IL-1β pro-inflammatory marker (p<0.05). Conclusion: The study findings corroborate the negative influence of COVID-019 on the RANK-RANKL-OPG system in favor of exaggerated osteoclastogenesis.
Abstract: Background: Coronavirus disease 2019 (COVID-19) influences bone metabolism by altering the RANK-RANKL-OPG system. However, this has not been validated, especially among Nigerians. Consequently, the current study explored the influence of the disease on this vital skeletal pathway among Nigerian healthcare workers (HCWs). Methods: This was a prospec...
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